Phospho irf1
WebJan 21, 2024 · The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader view, linking IRF1 to a wide range of ... Another transcription factor of the IRF family important for antiviral defenses [6, 18], IRF1, has previously also been implicated with the DNA damage response [26]. We hypothesized that upon genotoxic insult, IRF1 might be a downstream target of the RLR/IRF3 pathway, as reported for virus infection [18], and thereby … See more To investigate the molecular links between DNA damage-induced cell death and innate immune signaling, we used A549 human lung carcinoma cells, as they … See more In order to investigate the contribution of antiviral signaling cascades to the induction of DSB-induced cell death, we compared the impact of the major antiviral … See more Above we have shown that RLR/IRF3 signaling as well as expression of IRF1 are important for DNA damage-induced cell death. Furthermore, across all conditions … See more
Phospho irf1
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WebNational Center for Biotechnology Information WebBackground: IRF1. IRF1 (interferon regulatory factor 1) is a 45 kDa member of the IRF family of proteins. It is induced by TLR9 and INF-gamma stimulation, and positively regulates the expression of IFN-beta, iNOS and …
WebApr 19, 2024 · Mutation of Tyr613 on IL-27Rα decreased IL-27-induced STAT1 phosphorylation by 80% but had limited effect on STAT3 phosphorgylation. Strong receptor/STAT coupling by IL-27 initiated a unique gene expression program, which required sustained STAT1 phosphorylation and IRF1 expression and was enriched in classical … WebJun 3, 2024 · The antibodies were as follows: PD-L1 #13684, PD-L2 #82723, STAT1 #9172, JAK1 #3344, phospho-JAK1 #74129, IRF1 #8478, JAK2 #3230, phospho-JAK2 #3771; host rabbit (Cell Signalling Technology Europe, Frankfurt a.M., Germany); β-actin (#MAK6019); host mouse (Linaris, Dossenheim, Germany). Then, secondary antibodies against rabbit …
WebPhospho-IRF7 (Ser437/438) IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to ... WebNov 28, 2024 · IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcription factors. IRF1 protein expression is regulated by transient up-regulation in response to...
WebGet better batch-to-batch reproducibility with a recombinant antibody. Anti-IRE1 (phospho S724) antibody [EPR5253] (ab124945) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast production.
WebMay 14, 2024 · dna断裂的修复方式你知道吗？ - 大队书记于20240514发布在抖音，已经收获了29个喜欢，来抖音，记录美好生活！ therafin slide boardWebMay 1, 2024 · Following immunoprecipitation with anti-FLAG beads, western blots were performed using the anti-pT/S antibody and re-probed with anti-FLAG to determine total IRF1 protein, and a representative blot is shown. The ratio phospho-IRF1 to total IRF1 was quantified by densitometry, and data from three independent experiments are shown. signposting to mental health servicesWebBackground: Antiviral innate immunity depends on the combination of parallel pathways triggered by virus detecting proteins in the Toll-like receptor (TLR) family and RNA helicases, such as Rig-I (retinoic acid-inducible gene I) and MDA-5 (melanoma differentiation-associated antigen 5), which promote the transcription of type I interferons (IFN) and … therafinderWebPhosphoproteins are a group of proteins that are chemically bonded to a substance containing phosphoric acid. Phosphorylation and dephosphorylation of these proteins is … the raf in the korean warWeb(C) GST–IRF-1 (100 ng) was immobilized on a microtitre plate and incubated with a titration (0–100 ng) of MDM2. Protein binding was detected using an anti-MDM2 mAb and the … therafin knee adductorsWebPhospho-IRS1 (Tyr612) Antibody (44-816G) in IHC (P) Immunohistochemistry analysis of Phospho-IRS1 (pY612) showing staining in the cytoplasm and nucleus of paraffin-embedded human skeletal muscle tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM ... therafin chest strapWebBY-3451R phospho-TOPO II Alpha （Ser1106） 磷酸化DNA拓普西异构酶Ⅱ抗体 进口/国产 BY-1975R-FITC DAXX 死亡相关蛋白6抗体 进口/国产 BY-1404R-FITC IRF-1 干扰素调节因子1抗体 进口/国产 therafin wheelchair accessories