WebDec 28, 2016 · The findings suggest that ST6GAL1 has an inhibitory role in adipogenesis through integrin-β1 activation, providing new insights into the roles and regulation …
Frontiers Sialidase and Sialyltransferase Inhibitors: Targeting Pathoge…
WebApr 22, 2024 · been shown to inhibit the expression of ST6GAL1, resulting in reduced invasiveness of mouse HCC cells by inhibition of -2,6-linked sialylation and integrin- … WebDec 13, 2024 · Sialic acid sugars on mammalian cells regulate numerous biological processes, while aberrant expression of sialic acid is associated with diseases such as … unreduced chi-square
Targeting intracellular Neu1 for coronavirus infection treatment
WebFirst, ST6Gal-I and ST6Gal-II are involved in the α-2,6 sialylation of numerous cell membrane glycoproteins, including EGFR, CD45, β1 integrin, PECAM, Fas and immunoglobulin. 16 Second, it has been shown in B16 murine melanoma cell cultures that hypersialylation influences tumor growth and immune escape by alteration of T-cell activity, particularly … WebMar 29, 2024 · Elevated IgG expression in cancer cells has been implicated in exacerbated malignancy and poor clinical prognosis. Accumulating evidence indicates that a nonconventional sialylation modification is critical for the function of cancer-derived IgG, indicating the need for a better understanding of the regulatory mechanisms that control … WebSep 18, 2024 · Potent, cell-permeable, and subtype-selective sialyltransferase inhibitors represent an attractive family of substances that can potentially be used for the clinical treatment of cancer metastasis. These substances operate by specifically inhibiting sialyltransferase-mediated hypersialylation of cell surface glycoproteins or glycolipids, … unreduced dislocation