WebTherefore, the present studies investigated the immunopathogenic role of Tamm-Horsfall protein (THP) in (1) a rabbit model of tubulointerstitial nephritis; (2) a swine model of reflux nephropathy; and (3) patients with recurrent nephrolithiasis. The antigenic similarities between THP and uropathic bacteria were also studied. WebOct 24, 2014 · Uromodulin (UMOD)/Tamm-Horsfall protein, the most abundant human urinary protein, plays a key role in chronic kidney diseases and is a promising therapeutic …

Tamm-Horsfall protein in patients with kidney damage and diabetes

WebTamm-Horsfall protein (TH protein), a renal epithelial glycoprotein, was isolated originally from human urine [1, 2]. This membrane glycoprotein has several unusual physicochemical characteristics that may determine its role in normal tubular function in its distal nephron site of synthesis and in pathologic conditions. Variations of the ionic environment in the … WebThe Tamm–Horsfall protein is a large glycoprotein normally found only in the ascending limb of the loop of Henle extending into the very early portion of the distal tubule. Its presence in urine indicates tubular injury ( Bakris et al. 1990a; Berdon et al. 1969; Hoyer and Seiler 1987; Patel et al. 1964; Schwartz et al. 1970 ). california coast credit union hillcrest

Tamm-Horsfall protein in patients with kidney damage and diabetes

WebOct 3, 2003 · Tamm-Horsfall protein (THP) is a glycoprotein named after its discoverers Tamm and Horsfall [ 1 ]. It is the most abundant protein in human urine and a major constituent of urinary casts [ 2 ]. THP is present in the kidneys of all placental mammals, including humans [ 3 ]. THP is primarily localized to the thick ascending limb of the loop of … WebAug 19, 2024 · Tamm–Horsfall protein (THP) is the most abundant protein in normal urine and, at the same time, is known to interfere with most downstream biochemical urine analyses and, notably, uEV isolation. For this reason, we optimized a simple and robust method suitable for uEV isolation and applicable to crude urine analytics as well to rid … WebFeb 21, 2024 · Average daily urinary protein excretion in adults is 80 mg/day, with normal excretion considered to be <150 mg/day. Albumin represents approximately 15% of the daily urinary protein excretion in healthy people, … california coaster stations